This is educational information, not medical advice, and The Peptide University does not sell peptides, supplies, or supplements. Many compounds discussed here are sold as “research chemicals” and are not approved for human use outside of clinical trials. Laws vary by country, and nothing here is a recommendation to obtain or use anything. Talk to a qualified clinician about your own situation.
Sermorelin is a GHRH analogue that was FDA-approved (as Geref) for diagnostic use and growth-hormone deficiency, later discontinued commercially, and is now often prepared by compounding pharmacies. So it has an approval history but isn't a standard marketed product.
How it works
Like tesamorelin and CJC-1295, it works “upstream” — prompting the pituitary to release the body's own growth hormone rather than supplying GH directly.
The evidence
It has documented pharmacology and a diagnostic/therapeutic history, but robust modern outcome trials for anti-aging or body-composition uses are limited. Compounded use is a clinician-supervised, off-label space.
Safety
Effects track growth-hormone stimulation — injection-site reactions, flushing, and effects on glucose worth monitoring. Because it raises GH/IGF-1, the usual GH-axis cautions apply.
FAQ
QIs it FDA-approved now?
The original product was approved and later discontinued; today it's mainly compounded, which is a different regulatory situation.
QHow is it different from tesamorelin?
Both are GHRH-related, but tesamorelin has a current approved indication (HIV lipodystrophy); sermorelin's marketed product was discontinued.
Sources
This profile summarizes the following. Follow the links to read the originals — and remember that summaries age, so check for newer information.
- Growth hormone-releasing peptides: historical evidence review (PMC)
- Growth hormone peptides guide: CJC-1295, ipamorelin, tesamorelin (Meto)
Inclusion here is not endorsement of any source's claims; several are cited so you can compare how different outlets characterize the same evidence.
Questions & comments
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