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Hexarelin is a synthetic growth-hormone-releasing peptide, among the most potent at its receptor. It's investigational and not an approved consumer product.
How it works
It's a strong ghrelin/GH-secretagogue receptor agonist, and it also binds CD36, which has drawn research interest in cardiac tissue distinct from its GH effect.
The evidence
It shows the highest GH-secretagogue potency of the group in studies, plus some cardiac research signals. Human anti-aging/body-composition efficacy is unconfirmed, and receptor desensitization with continued use is a noted issue.
Safety
GH-stimulation effects plus potential cortisol/prolactin elevation; the CD36 cardiac activity is a reason for caution rather than reassurance. Long-term human safety is not established.
FAQ
QIs it 'stronger' than the other GHRPs?
It's the most potent at the receptor, but potency isn't the same as being safer or better for any goal.
QIs it approved?
No — investigational.
Sources
This profile summarizes the following. Follow the links to read the originals — and remember that summaries age, so check for newer information.
- Growth hormone-releasing peptides: historical evidence review (PMC)
- GHRP metabolites after nasal administration (PubMed)
Inclusion here is not endorsement of any source's claims; several are cited so you can compare how different outlets characterize the same evidence.
Questions & comments
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